Development of PLGA-loaded ticagrelor magnetic microspheres: towards prevention of post PCI thrombosis.

Motivation: After percutaneous coronary intervention, systemic dual antiplatelet therapy prevents thrombosis which may increase the bleeding risk, especially in populations at high risk of bleeding. Goal(s): The aim of this study was to develop PLGA-Fe3O4-Ticagrelor microspheres (PFTm), for local infusing to injured artery wall for preventing thrombosis. Approach: Firstly, the abdominal aorta of rabbits was injured by balloon, and PLGA-Fe3O4-Ticagrelor microspheres were infuded into the injured artery, and T2WI imaging was performed. Results: PFTm was successfully developed, which can effectively prevent thrombosis. Impact: This study provides a new concept of local infusion for prevention of thrombosis after PCI.