Combining brain MRI and MRS, neuropsychological testing and brain-derived cell-free DNA level for the early detection of Alzheimer’s Disease
Motivation: There is a lack of biomarkers in elderly people with ongoing subjective or clinical cognitive decline that indicate evolution to Alzheimer’s disease, necessary for the timely identification of candidate for pharmacological treatment or cognitive rehabilitation. Goal(s): Our goal was to determine whether combining MR, neuropsychological and biological data could provide robust biomarkers for this purpose. Approach: We evaluated patients with subjective cognitive decline, mild cognitive impairment, Alzheimer’s disease and healthy individuals, using a multimodal approach. Results: We identified candidate biomarkers of condition worsening at early stages of the disease among alterations possibly explained by ongoing neurodegeneration. Impact: Our results support the combined investigation of imaging, biological and neuropsychological data to detect patients in the early stages of the Alzheimer’s disease spectrum, who may undergo active neurodegeneration and worsening of the condition.
Authors
- Caterina Tonon (ORCID: https://orcid.org/0000-0002-0506-499X)
- Susy Ferrari
- Raffaele Lodi (ORCID: https://orcid.org/0000-0003-3878-304X)
- Chiara Pirazzini (ORCID: https://orcid.org/0000-0001-8248-0295)
- Luca Morandi (ORCID: https://orcid.org/0000-0002-3810-9760)
- Lucia Guidi (ORCID: https://orcid.org/0000-0002-2472-720X)
- Luisa Sambati (ORCID: https://orcid.org/0000-0002-5939-7933)
- David Neil Manners (ORCID: https://orcid.org/0000-0002-2404-1101)
- Camilla Pellegrini (ORCID: https://orcid.org/0000-0003-2636-477X)
- Micaela Mitolo (ORCID: https://orcid.org/0000-0003-0533-7318)
- Rossella Santoro (ORCID: https://orcid.org/0000-0001-8771-5145)
- Giovanni Sighinolfi (ORCID: https://orcid.org/0000-0003-0236-6164)
- Pietro Cortelli (ORCID: https://orcid.org/0000-0002-3633-8818)
- Virginia Pollarini (ORCID: https://orcid.org/0009-0007-2259-2819)
- Elena Cantoni (ORCID: https://orcid.org/0009-0004-8495-0173)
- R. C. Francesco
- Maria Giulia Bacalini
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4200
- Primary Topic
- Gene expression and cancer classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00