Value of feature-tracking myocardial strain analysis in evaluation patients with immune checkpoint inhibitor (ICI) associated myocarditis

Motivation: Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). More diagnostic tools are needed beside enzymes. Goal(s): Data on CMR characteristics of ICI myocarditis is limited, especially the new strain analysis. Approach: The study compared the cardiac functional and stain parameters between patients with ICI associated myocarditis and controls. The parameters included LVEF, CO, CI, EDV/BSA, ESV/BSA, and SV/BSA, incidence rate of myocardial edema and LGE, LS, CS, RS (global and segmental). Results: For patients with ICI associated myocarditis, LVEF, ESV/BSA, CS (basal, mid, apical and global) and LS (mid, apical and global) may be effective parameters to identify myocardial injury. Impact: Some CMR strain parameters and cardiac function indicators significantly impaired, which may be helpful for early detection and to evaluate treatment effectiveness of ICI associated myocarditis.