BTS POSE: Rapid High Resolution 3D Quantitative MT Imaging using Novel Position Encoding and Parallel Imaging

Motivation: Current quantitative MT (qMT) methods have low resolution, limiting their ability to assess tissue microstructure. Goal(s): Introduce a new qMT approach that achieves 3D isotropic high-resolution qMT within a clinically feasible scan time. Approach: BTS POSE applies unique subvoxel-shifts along the acquisition parameter dimension, combined with the BTS MT signal model, to generate MT parameter maps with enhanced resolution. Results: in-vivo results show that BTS POSE 1) enhances the image resolution at no cost of additional scan time, 2) can be combined with parallel imaging to achieve further acqusition acceleration, and 3) generates quantitative maps corresponding well with literature values. Impact: BTS POSE uses position encoding to generate 3D MT parameter maps with enhanced resolution. This enables microstructure assessment of tissues such as myelin, an important biomarker for neurodegenerative diseases.