Detecting glucose metabolism abnormality in Six-Month-Old AD mice using deuterium magnetic resonance imaging
Motivation: Impaired brain energy metabolism at early stage is found to be the driving factor of Alzheimer’s Disease (AD) progression. Goal(s): The study aim to investigate the potential of using deuterium magnetic resonance imaging to characterize the glucose metabolism in AD mouse model. Approach: Deuterium magnetic resonance spectroscopic imaging with the administration of [2,3,4,6,6’-2H5]-D-Glucose in 5xFAD and C57 mice. Results: Our preliminary results indicate higher glutamine/glutamate (Glx) production rate in 5xFAD mice compared to normal mice, especially in the hypothalamus region. Impact: Our work may shed light on developing new method in the early detection of AD based on the glucose metabolism abnormality.
Authors
- Yi-Jun Zhou (ORCID: https://orcid.org/0000-0001-9248-234X)
- Chao Zou (ORCID: https://orcid.org/0000-0002-6387-7809)
- Junyi Duan (ORCID: https://orcid.org/0000-0002-1484-033X)
- Enhua Xiao (ORCID: https://orcid.org/0000-0002-3281-6384)
- Ye Li (ORCID: https://orcid.org/0000-0002-2898-5345)
- Xin Liu (ORCID: https://orcid.org/0000-0003-3256-2940)
- Shiyi Zhang (ORCID: https://orcid.org/0000-0002-9375-5992)
- Jiaxu Li (ORCID: https://orcid.org/0009-0006-2582-4171)
- Peng Hao (ORCID: https://orcid.org/0000-0002-6445-8331)
- Ganghan Yang (ORCID: https://orcid.org/0009-0000-6860-1636)
- Qian Wan
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3053
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00