Quantitative Placental R2* Mapping on Rhesus Macaques with Thrombotic and Inflammatory Injury Model
Motivation: Pregnancy complications are often associated with placenta dysfunction, which lacks non-invasive assessment in early pregnancy. Goal(s): Evaluating placental R2* as a non-invasive and quantitative biomarker to identify and monitor pregnancy complications. Approach: We introduce a novel thrombotic and inflammatory placental injury model of rhesus macaques and report mean values, histograms, and spatial distribution of placental R2* based on blood oxygenation level dependent (BOLD) MR imaging at different gestational ages before and after iron nanoparticle (ferumoxytol) administration. Results: Higher overtime and post-contrast increase in mean values and more heterogeneous spatial patterns of R2* are observed in placentas with induced injury. Impact: A refined nonhuman primate model for thrombosis and inflammation is introduced for investigating placental pathology. Larger R2* increases over time and immediately after ferumoxytol injections suggest the potential for R2* to be an indicator of pathology with or without contrast.
Authors
- Logan Keding
- Thaddeus G. Golos (ORCID: https://orcid.org/0000-0002-7897-4337)
- Kevin E. Johnson (ORCID: https://orcid.org/0000-0001-8968-6974)
- R. Liu (ORCID: https://orcid.org/0000-0003-0853-9863)
- Puja Basu (ORCID: https://orcid.org/0000-0003-4051-7998)
- Jitka Starekova (ORCID: https://orcid.org/0000-0002-4285-3090)
- Aleksandar K. Stanic (ORCID: https://orcid.org/0000-0003-1946-6436)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Jessica Vázquez (ORCID: https://orcid.org/0000-0002-8052-3850)
- Dinesh Shah (ORCID: https://orcid.org/0000-0001-7599-9945)
- Ante Zhu (ORCID: https://orcid.org/0000-0001-6251-2341)
- Andrés Mejía (ORCID: https://orcid.org/0000-0001-6088-3595)
- Heather A. Simmons (ORCID: https://orcid.org/0000-0002-4862-7289)
- Ruiming Chen (ORCID: https://orcid.org/0009-0005-6551-7902)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0176
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00