MRI-based Biological Age Estimation for Multiple Organs in the UK Biobank Cohort

Motivation: MRI is a valuable tool for providing health-related information, including visualizing age-associated changes. Aging is influenced by chronic diseases, and assessing the true organ-specific biological age is essential for accurate diagnosis. Goal(s): Development of an organ-specific age estimation for investigation in large imaging cohort with associated non-imaging information. Approach: While prior studies focused on age estimation from non-imaging data or single organs, we propose a multi-organ age estimation framework, operating on brain, cardiac, and abdominal MRIs, and OCT scans. Results: Our results prove the feasibility of imaging-based organ age estimation and initiate further investigations to identify risk factors for accelerated aging. Impact: Reliable imaging-based estimation of biological age in multiple organ systems facilitates research efforts to identify risk factors of accelerated aging, advancing the goal of age-related phenotyping.