Acute changes of cerebral hemodynamics, metabolism and blood-brain barrier permeability in response to aerobic exercise

Motivation: How does single bout of exercise affect brain oxygen metabolism and BBB permeability in addition to perfusion remains unclear. Goal(s): This study aims to dynamically monitor the acute changes in cerebral physiology subsequent to a singular aerobic exercise training sessionApproach: Multiple indices were quantified, including CBF as gauged by PC MRI, Yv and CMRO2 as assessed by TRUST MRI, BBB E and PS as determined via WEPCAST MRI. Results: We found a significant increase in participants' CBF and CMRO2 post-exercise, post-exercise stability in E and a significant increase in PS were also observed. Impact: Our findings suggest that a singular bout of moderate-intensity aerobic exercise can induce acute alterations in cerebral hemodynamics, metabolic processes, and blood-brain barrier permeability.These findings may shed light on the initial stages of the clinical implications of aerobic exercise.