ASL blood-brain barrier permeability is associated with amyloid and cognitive impairment
Motivation: Blood-brain barrier (BBB) permeability changes may be implicated in Alzheimer’s Disease (AD) pathophysiology. Goal(s): To investigate if the exchange time (Tex) of water across the BBB is associated with cognitive and amyloid status. Approach: We measured Tex with a multi-echo arterial spin labeling MRI sequence in 116 adults older than 50 years and studied its association with cognition (cognitively normal vs mild cognitive impaired) and amyloid (A- vs A+) status. Results: BBB water permeability is increased in A+ participants and in patients with MCI, compared to healthy controlsImpact: Our results suggest that multi-TE ASL MRI BBB water permeability can be used as a potential early imaging biomarker of AD pathophysiology.
Authors
- Markus H. Sneve (ORCID: https://orcid.org/0000-0001-7644-7915)
- Lene Pålhaugen
- David Vállez García (ORCID: https://orcid.org/0000-0003-3308-3167)
- Anders M. Fjell (ORCID: https://orcid.org/0000-0003-2502-8774)
- Klaus Eickel (ORCID: https://orcid.org/0000-0002-5700-2029)
- Oliver Marcel Geier (ORCID: https://orcid.org/0000-0003-3919-7579)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Sandra Tecelão
- Amnah Mahroo (ORCID: https://orcid.org/0009-0005-8480-0965)
- Kristine B. Walhovd (ORCID: https://orcid.org/0000-0003-1918-1123)
- Atle Bjørnerud (ORCID: https://orcid.org/0000-0002-3486-3141)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Beatriz Padrela (ORCID: https://orcid.org/0000-0001-6836-9443)
- Per Selnes (ORCID: https://orcid.org/0000-0001-5131-9757)
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
- D. G. T. Thomas
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0732
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00