129Xe HyperCEST Imaging of a Novel R3-Noria-methanesulfonate Supramolecular Cage using a 3.0 T Clinical MRI

Motivation: In the setting of molecular MRI, designing a contrast agent that can be applied in clinical studies and which offers high sensitivity poses a significant challenge. Goal(s): We aimed to demonstrate a novel water-soluble R3-Noria-MeSO3H macrocycle as a viable supramolecular cage agent for 129Xe molecular imaging. Approach: Hyperpolarized 129Xe chemical exchange saturation transfer MR imaging and spectroscopy were conducted in vitro using a 3.0T clinical MRI scanner. Results: We demonstrated that R3-Noria-MeSO3H produces a superior HyperCEST effect and investigated its dependence on concentrations in various aqueous solutions. Impact: The introduction of the novel R3-Noria-MeSO3H macrocycle for HP 129Xe HyperCEST imaging marks a critical milestone, establishing a new frontier in 129Xe molecular imaging with heightened sensitivity and potential for advancing clinical applications in diagnostic precision and therapeutic monitoring.