Intratumoral Habitat and Peritumor Radiomics for Progression Risk Stratification of Patients with Soft Tissue Sarcoma: A Multicenter Study

Motivation: Increasing the identification accuracy of patients with high risk of progression could help guide treatment decision in soft tissue sarcoma (STS). Goal(s): To establish a radiomics nomogram that incorporated tumor habitat and peritumor features and validate its performance to predict tumor progression in patients with STS. Approach: A nomogram combining radiomics based on intratumoral habitat and peritumorwith clinical information was established. Results: This nomogram predicts tumor progression in STS patients and stratifies them according to the risk of progression. Impact: Combining radiomics features derived from the intratumoral habitat and peritumoral region resulted in superior performance for predicting progression-free-survival in patients with STS, which is helpful for clinical decision making.