Spin and gradient echo multiple overlapping echo detachment (SAGE-MOLED) for high-fidelity T2-T2* mapping and simultaneous DSC-DCE imaging

Motivation: Conventional spin and gradient echo EPI (SAGE-EPI) sequence has limited spatial resolution and suffers from geometric distortion. Goal(s): Our goal was to develop a high-fidelity simultaneous T2 and T2* mapping technique used for dynamic MR imaging. Approach: We developed a single-shot spin and gradient echo multiple overlapping-echo detachment acquisition (SAGE-MOLED) method with deep learning reconstruction. The proposed method was tested in phantom and in vivo human brains, and a single-dose contrast dynamic imaging was performed on a clinical case. Results: SAGE-MOLED achieves distortion-free high-precision T2 and T2* mapping compared to gold-standard methods and was successfully used in simultaneous DSC-DCE imaging. Impact: Rapid high-fidelity T2 and T2* mapping can be achieved using our proposed SAGE-MOLED technique, which further enables leakage-corrected simultaneous DSC and DCE imaging at 1.7×1.7×4.0 mm3 spatial resolution and 1.9 s temporal resolution.