Normative trajectories of R1, R2*, and Susceptibility values of the healthy human brain cortex
Motivation: Quantitative MRI (qMRI) offers sensitive and specific measures to study age-related microstructural changes in the brain. However, models assessing age trajectories in qMRI brain properties are often incomparable among centers. Goal(s): Develop normative models reflecting aging trajectories and assess the impact of bi-centric, non-fully matched protocols in brain aging studies. Approach: Investigating age trajectories in cortical regions using polynomial regression models, focusing on quantitative R1, R2*, and susceptibility mapping (QSM). Results: We validated data harmonization by observing the impact on normative trajectories using bicentric data, where we noted significantly different maturation and aging inflections for R1 and R2* trajectories across cortical regions. Impact: This bi-centric, multi-parameter qMRI study investigates age-dependent variations across cortical regions, offering a valuable reference for subsequent qMRI aging research and emphasizing age effects on the cortical surface.
Authors
- Sabine Schädelin (ORCID: https://orcid.org/0000-0002-1150-0962)
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- David G. Norris (ORCID: https://orcid.org/0000-0002-3699-6917)
- José P. Marques (ORCID: https://orcid.org/0000-0001-8157-8864)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Michelle G. Jansen (ORCID: https://orcid.org/0000-0002-1244-5715)
- Kwok‐Shing Chan (ORCID: https://orcid.org/0000-0001-8427-169X)
- Po‐Jui Lu (ORCID: https://orcid.org/0000-0001-6031-6865)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Muhamed Baraković (ORCID: https://orcid.org/0000-0001-8557-9223)
- Marcel P. Zwiers (ORCID: https://orcid.org/0000-0001-5483-2935)
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Lester Melie‐García (ORCID: https://orcid.org/0000-0001-5602-8916)
- Xinjie Chen (ORCID: https://orcid.org/0009-0009-7031-9985)
- Ludwig Kappos
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0576
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00