Brain arterial remodeling and incident dementia: the Atherosclerosis Risk in Communities (ARIC) Study

Motivation: We aimed to address the gap in understanding the neurovascular contributions to dementia risk in a US community-based study, recognizing the need to consider arterial geometry factors and cerebral small vessel disease (CSVD). Goal(s): Our study sought to investigate the relationship between brain arterial remodeling and incident dementia risk, focusing on how arterial geometry and CSVD factor into this complex equation. Approach: Our approaches involved analyzing data from a US community-based study to assess the impact of arterial remodeling, arterial geometry, and CSVD on dementia risk. Results: Our study's core findings indicate an increased risk of incident dementia associated with brain arterial remodeling. Impact: Our model is promising for the prediction of cognitive decline and dementia diagnosis based on the MRA measurements.