Optimized deuterium metabolic imaging (DMI) for quantitative analysis of lactate in intracerebral hemorrhages

Motivation: Lactate, as an important metabolism product after intracerebral hemorrhage (ICH), plays a crucial role in the pathophysiology and prognosis. Deuterium metabolic imaging (DMI), as a potentially transformative technique, can localize abnormal metabolism associated with lactate. Goal(s): Optimize deuterium coils and sequences to improve the signal-to-noise ratio of DMI, and quantitatively analyze lactate changes after ICH with optimized techniques. Approach: Propose the active decoupling 2H/1H dual-tuned transceiver coil and CSI-bSSFP sequence for DMI and measure the dynamical lactate metabolism in three groups of rats before and after ICH. Results: DMI can measure the lactate metabolic changes at different time points after ICH. Impact: This study presents a non-invasive technique for monitoring the lactate metabolic changes after ICH, which holds clinical potential in determining the time of onset, treatment plan, and real-time response evaluation.