Multiparametric Renal MRI Reveals Ethnic Disparities in Multiple Kidney Function Markers in Asian Preadolescents
Motivation: Within Singapore's multiethnic population, Indians and Malays have a higher burden of chronic kidney disease than Chinese. While this has been attributed to higher prevalence of hypertension, diabetes and dyslipidemia, it is not clear if Indians and Malays already have preexisting subclinical renal alterations. Goal(s): Assess ethnic differences in kidney function markers in healthy Asian preadolescents using multiparametric MRI and physiological assessments. Approach: Identify adverse renal function using multiparametric MRI (volumetry, diffusion, perfusion, oxygenation) and physiological assessments (urine albumin, estimated glomerular filtration rate, blood pressure)Results: Indian and Malay preadolescents showed multiple renal alterations which predate the development of diabetes, hypertension or dyslipidemia. Impact: Detailed renal phenotyping of Asian preadolescents using multiparametric renal MRI and physiological assessments identified ethnic disparities in multiple renal function markers, which predate the development of diabetes, hypertension or dyslipidemia, and may help explain the predisposition for chronic kidney disease.
Authors
- Yap Seng Chong (ORCID: https://orcid.org/0000-0002-7232-8473)
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- Shang Chee Chong (ORCID: https://orcid.org/0000-0002-7155-9691)
- Shiao‐Yng Chan (ORCID: https://orcid.org/0000-0002-3530-3023)
- S. Sendhil Velan (ORCID: https://orcid.org/0000-0002-4096-0722)
- Yeshe Kway (ORCID: https://orcid.org/0000-0001-6726-2425)
- Liangjian Lu (ORCID: https://orcid.org/0000-0002-8363-4353)
- Jia Ying Toh (ORCID: https://orcid.org/0000-0001-7734-7465)
- Chang‐Yien Chan (ORCID: https://orcid.org/0000-0001-5841-1417)
- Karen M. Moritz (ORCID: https://orcid.org/0000-0002-8085-0034)
- Kok Hian Tan (ORCID: https://orcid.org/0000-0003-1945-0266)
- Navin Michael (ORCID: https://orcid.org/0000-0002-6170-2108)
- Delicia Shu Qin Ooi (ORCID: https://orcid.org/0000-0001-8677-0126)
- Yung Seng Lee (ORCID: https://orcid.org/0000-0002-1253-0557)
- Fabian Yap (ORCID: https://orcid.org/0000-0003-1083-7958)
- Bernd Kühn (ORCID: https://orcid.org/0000-0002-6852-2433)
- Suresh Anand Sadananthan (ORCID: https://orcid.org/0000-0001-5938-1694)
- Mary E. Wlodek (ORCID: https://orcid.org/0000-0002-8490-9099)
- Marielle V. Fortier (ORCID: https://orcid.org/0000-0002-3294-1054)
- Keith Godfrey
- Kashthuri Thirumugan
- Peter Gluckman
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0781
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00