Chronic Obstructive Pulmonary Disease is Associated with Impaired Cardiac Hemodynamics: A SPIROMICS HF Study
Motivation: Previous studies have suggested impaired cardiovascular function in patients with chronic obstructive pulmonary disease (COPD). However, the association between lung disease severity and the degree of cardiac hemodynamic impairment is not well understood. Goal(s): We aimed to characterize the hemodynamic changes seen in COPD in order to gain insight into the mechanisms relating COPD and heart failure. Approach: We analyzed 4D-flow derived hemodynamics in a preliminary sample of 72 participants from the SPIROMICS-HF study. Results: We found that impaired hemodynamics in the right atrium (blood flow kinetic energy and velocity) and pulmonary artery (flow stasis and velocity) are associated with greater COPD severity. Impact: This study represents a key step in exploring the cardiopulmonary hemodynamic interaction in chronic obstructive pulmonary disease.
Authors
- Timothy W. Houston
- Joyce Schroeder (ORCID: https://orcid.org/0000-0002-7451-4886)
- Sachin Jambawalikar (ORCID: https://orcid.org/0000-0003-1839-6798)
- Michael Backman
- Wei Shen (ORCID: https://orcid.org/0000-0003-4838-4923)
- Martin R. Prince (ORCID: https://orcid.org/0000-0002-9883-0584)
- Steven G. Lloyd (ORCID: https://orcid.org/0000-0001-6843-0224)
- Michael Markl (ORCID: https://orcid.org/0000-0002-7686-1128)
- R. Graham Barr
- Prachi Agarwal (ORCID: https://orcid.org/0000-0002-4439-6970)
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Dalane W. Kitzman (ORCID: https://orcid.org/0009-0000-5274-0826)
- Bharath Ambale‐Venkatesh (ORCID: https://orcid.org/0000-0002-2330-2373)
- David Dushfunian (ORCID: https://orcid.org/0000-0002-0628-1961)
- João L. M. P. de Lima (ORCID: https://orcid.org/0000-0002-0135-2249)
- Yoo Jin Lee (ORCID: https://orcid.org/0000-0003-3830-7051)
- James Carr
- David Bluemke
- Paul Finn
- Christopher B. Cooper
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0101
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00