Testing the utility of Dynamic Susceptibility Contrast (DSC)-Perfusion toolbox for mapping the characteristics of mouse brain perfusion

Motivation: Perfusion studies using DSC-MRI offer insights into vascular aspects of cerebral pathophysiology by allowing us to estimate viable perfusion characteristics. Goal(s): Previous studies have shown successful implementation of DSC MRI toolbox to characterise human brain perfusion, but its application to animal data remains unexplored. Our goal is to characterize perfusion parameters in mouse model using DSC-MRI-toolbox. Approach: We slightly modified and implemented DSC-MRI-toolbox to meaure CBV, CBF and MTT in different regions of mouse brain such as cortex, hippocampus and thalumus. Results: Initial data analysis shows a successful implementation of the DSC-MRI-toolbox and allowing us to estimate perfusion parameters in preclinical data. Impact: A successful implementation of DSC-MRI toolbox in mouse models will allow us to estimate perfusion parameters such as CBV, CBF, MTT and CBV with leakage correction, which will be important for characterising tissue viability in stroke and brain injury models.