Neurovascular coupling dysfunction of hippocampus-visual network in Post-Concussive Syndrome

Motivation: The clinical relevance and modifications in perfusion and neural activity remain undetermined in Post-Concussive Syndrome. Goal(s): To delineate changes in NVC during the pathophysiology of PCS, multimodal magnetic resonance imaging was performed on patients and healthy controls. Approach: Five imaging-markers elucidates the relationship between neuronal activity and perfusion. Dynamic causal modeling evaluates associations with disease transitions, clinical variables, and information flow. Results: The fALFF-CBF of the hippocampal was diminished, and the ReHo-CBF in the Temporal-Occipital cortex decreased, correlating with declining spatial processing and memory tasks. Impact: The distinctive pattern of changes in neurovascular coupling in the hippocampal , temporal-occipital cortex provide fresh insights into PCS