Dorsal nigral hyperintensity abnormality in 7T MRI is a biomarker for diagnosis of Parkinson’s disease and atypical parkinsonisms
Motivation: The dorsal nigral hyperintensity (DNH) abnormality is a characteristic feature of PD and 7T MRI has proved useful for its visualization. Goal(s): To investigate the diagnostic efficiency of DNH abnormality at different stages of PD and in atypical parkinsonisms using 7T MRI. Approach: PD, RBD, MSA-P, MSA-C, and PSP patients and controls underwent 7T T2* with DNH abnormality assessed for diagnostic performance. R2* mapping and principal component analysis were performed in substantia nigra. Results: MSA-C and RBD demonstrated higher preservation rate of DNH than PD, MSA-P, and PSP. DNH scoring criteria proved an optimal diagnostic method of PD, RBD, MSA-P, MSA-C, and PSP. Impact: MSA-C and RBD patients had higher dorsal nigral hyperintensity (DNH) preservation rate compared with PD, MSA-P, and PSP. The DNH scoring criteria proved an optimal diagnostic method of PD, RBD, MSA-P, MSA-C, and PSP.
Authors
- Huizi Ma (ORCID: https://orcid.org/0000-0002-3845-8020)
- Tao Wu (ORCID: https://orcid.org/0000-0002-2400-6509)
- Junhong Zhou (ORCID: https://orcid.org/0000-0002-7931-7646)
- Joyce Ching Mei Lam (ORCID: https://orcid.org/0000-0001-9368-4752)
- Tao Feng (ORCID: https://orcid.org/0000-0002-8530-4622)
- Rui Yan (ORCID: https://orcid.org/0000-0002-8495-1289)
- Ning Wei (ORCID: https://orcid.org/0000-0001-8931-8995)
- Zhan Wang (ORCID: https://orcid.org/0000-0002-1335-4698)
- Yue Suo (ORCID: https://orcid.org/0000-0002-0632-0262)
- Zhijin Zhang (ORCID: https://orcid.org/0000-0001-8893-2264)
- Dongning Su
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8220-8443)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Xinyao Liu (ORCID: https://orcid.org/0009-0007-0478-8981)
- Wanlin Zhu (ORCID: https://orcid.org/0000-0002-0525-657X)
- Huiqing Zhao
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4388
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00