Exploring Preclinical Imaging Biomarkers and Progressive Degeneration in Alzheimer's Disease

Motivation: Preclinical stages of AD offer potential windows for intervention. Investigating individuals in this stages can yield valuable biomarkers and deepen our understanding of disease progression mechanisms. Goal(s): We aim to investigate brain degeneration mechanisms during AD's preclinical stages and explore early diagnostic markers in gray matter and superficial white matter alterations. Approach: This study involved 411 participants (including preclinal stages, aMCI and AD) and their diffusion and structural MRI and neuropsychological tests, to assess brain changes. Results: Cortical atrophy in the temporal lobe may be a trigger for disease onset, while extensive SWM degeneration appears to be associated with disease progression in AD. Impact: This study provides crucial insights into brain changes in early stages of AD. Identified imaging biomarkers are valuable for early diagnosis and interventions, and the proposed degeneration patterns enhance our understanding of AD's pathophysiology.