Metabolic and imaging phenotypes associated with RB1 loss in castrate resistant prostate cancer
Motivation: The progression of prostate cancer is marked by both RB1 and T53 inactivation and higher 18FDG-PET uptake, but it's unclear whether RB1 or TP53 inactivation drives increased glucose import. Goal(s): Can metabolic changes be used as a biomarker for RB1 and TP53 loss?Approach: Metabolomic analysis by NMR and IC-MS for a comprehensive measure of metabolic changes ex vivo and and hyperpolarized MRI to measure the Warburg effect in vivo. Results: 18FDG uptake was unaffected by loss of either RB1 or TP53. RB1 and TP53 did induce a series of other metabolic changes which could be detected in vivo by hyperpolarized MRIImpact: Neuroendrocrine prostate cancer is a life-threatening progression of prostate cancer that is characterized by mutations in two key genes. Hyperpolarized MRI may enhance early diagnosis of NEPC without biopsy.
Authors
- Murali Cherukuri
- Margaret White
- Aian Alilin
- Jeffrey Brender (ORCID: https://orcid.org/0000-0001-7487-6169)
- Ye Yang (ORCID: https://orcid.org/0000-0003-0228-5102)
- Fahim Ahmad (ORCID: https://orcid.org/0000-0002-7216-5539)
- Jürgen Seidel (ORCID: https://orcid.org/0000-0001-7240-5726)
- Sonam Raj (ORCID: https://orcid.org/0000-0002-3633-2299)
- Kazutoshi Yamamoto (ORCID: https://orcid.org/0000-0001-9405-5421)
- Colleen P. Olkowski (ORCID: https://orcid.org/0000-0002-2370-0582)
- Brian J. Capaldo (ORCID: https://orcid.org/0000-0003-1244-8884)
- Stephen Adler (ORCID: https://orcid.org/0000-0002-4399-6923)
- Peter L. Choyke (ORCID: https://orcid.org/0000-0003-1086-8826)
- Supreet Agarwal (ORCID: https://orcid.org/0000-0001-7924-6852)
- Kathleen Kelly
- Daniel R. Crooks (ORCID: https://orcid.org/0000-0002-9198-4089)
- Anita Ton
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0702
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00