The feasibility of APT and IVIM in renal malignancies: A Preliminary Study

Motivation: Amide proton transfer (APT) imaging studies are gradually expanding to the body, with few applications in renal diseases and a lack of tumor studies. Goal(s): In the present study, we aimed to investigate the ability of APT and voxel-wise intravoxel incoherent motion (IVIM) imaging to detect renal malignancies. Approach: We preliminarily analyzed the ability of APT imaging to discriminate malignant tumors from normal renal tissues, combined with each parameter of IVIM imaging, which has high diagnostic efficacy. Results: The results showed that APT imaging was feasible and superior to IVIM imaging in discriminating renal malignant tumors from normal renal tissues. Impact: APT imaging has potential clinical applications in diagnosing of renal malignancies and provides a reference for subsequent accurate studies of APT imaging of renal tumors.