Amido-proton transfer imaging combines DWI to evaluate ischemic penumbra in wake-up stroke patients: A Feasibility study

Motivation: Ischemic Penumbra (IP) is an Ischemic tissue that is "basically reversible” during effective treatment. amide proton transfer-weighted (APT) imaging based on the PH value of biological tissues may have certain application value in evaluating the range of ischemic penumbraGoal(s): This study aimed to explore if APTw imaging has the clinical potential to predict Ischemic PenumbraApproach: This study intends to apply APTw imaging technology to wake-up stroke patients to explore whether this technology can more accurately evaluate the range of IP compared with ASL technologyResults: The APTw-DWI mismatch model has the potential to evaluate the ischemic penumbra in wake-up stroke patientsImpact: APTw combined with DWI provides a new method to distinguish ischemic penumbra in patients with wake-up stroke accurately.