Investigating Brain Health in Coronary Artery Disease: Vascular and Metabolic Biomarkers, Cognition, and Implications
Motivation: There is limited understanding regarding the physiological mechanisms underlying the impact of coronary artery disease (CAD) on brain health. Goal(s): In this study, we sought to explore the influence of CAD on vascular and metabolic biomarkers. Approach: Specifically examining Cerebrovascular Reactivity (CVR), Cerebral Blood Flow (CBF), and Oxygen Extraction Fraction (OEF) in the brain, and how these factors relate to cognitive performance. Results: Our initial findings, based on a preliminary dataset, indicate that individuals with CAD exhibit reduced CBF and CVR, with increased OEF across several brain regions. Low CVR and high OEF are also associated with poorer executive function in these regions. Impact: The influence of coronary artery disease (CAD) on brain health remains unclear. We show that CAD is associated with elevated OEF and reduced CVR and CBF. High OEF and low CVR are linked to poorer cognition, especially executive functions.
Authors
- Dalia Sabra
- Anil Nigam (ORCID: https://orcid.org/0000-0002-0253-7990)
- Brittany Intzandt (ORCID: https://orcid.org/0000-0001-8475-988X)
- Stefanie A Tremblay (ORCID: https://orcid.org/0000-0001-6026-6239)
- Louis Bherer (ORCID: https://orcid.org/0000-0003-2258-8194)
- Thomas Vincent (ORCID: https://orcid.org/0000-0001-6202-1585)
- Dajana Vuckovic (ORCID: https://orcid.org/0000-0002-7764-8492)
- Julia Huck (ORCID: https://orcid.org/0000-0002-5701-8506)
- Mathieu Gayda (ORCID: https://orcid.org/0000-0003-1721-2299)
- Safa Sanami
- Lucy Wright (ORCID: https://orcid.org/0000-0001-9600-5911)
- Claudine Joëlle Gauthier (ORCID: https://orcid.org/0000-0002-5137-5019)
- Josep Iglésies (ORCID: https://orcid.org/0000-0003-3269-6455)
- Zacharie Potvin-Jutras (ORCID: https://orcid.org/0009-0003-9656-2728)
- C. Gagnon
- Ali Rezaei
- Amélie Mainville-Berthiaume
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3357
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00