Study on the changes in low-frequency amplitude and regional homogeneity of the cerebral cortex in children with congenital deafness.

Motivation: To investigate the changes in low frequency fluctuation amplitude (mALFF) and regional homogeneity (ReHo) in the brains of children with congenital Sensorineural hearing loss (SNHL) by resting state fMRI. Goal(s): The primary objective of this research was to improve understanding of the changes in neural functional activity within the cortical regions of SNHL patients during a resting state. Approach: The study's goal is to establish a neuroimaging pathological foundation, which could potentially provide significant neuroimaging biomarkers. Results: These biomarkers could aid in the clinical selection of appropriate candidates for cochlear implantation (CI), thereby enhancing the effectiveness of this therapeutic intervention. Impact: The findings offer a fresh insight into the neuropathological mechanisms that drive functional reorganization in the cerebral cortex of children with congenital deafness after auditory deprivation. Moreover, these results provide valuable neuroimaging evidence for assessing the prognosis of post-CI patients.