The individuality of human brains when performing tasks

Motivation: It is imperative to study individual brain functioning when performing tasks. Goal(s): This study aims to develop a novel method to investigate the individuality of human brain functions. Approach: The temporal correlation of a task-evoked activity with the time signal of every point in the brain quantifies the whole brain’s functional co-activity (FC). The spatial correlation of the FC maps of two task trials over the entire brain quantifies the degree of their co-activity, which measures the variation of brain activity when performing these two tasks. Results: The measured trial-to-trial variation of the whole brain’s activity quantified individual brain functioning when performing tasks. Impact: This study presents a novel method to investigate individual brain functioning when performing tasks. The quantified relationship of the whole brain activity with each performed task trial may characterizes the neural bases responsible for individual behavioral and clinical traits.