Cerebral hemodynamics in the ageing marmoset monkeys using ECG-synchronized PCMRI.

Motivation: Some cerebrovascular function alterations and cognitive changes are related to ageing. We investigated this issue in marmoset monkeys, offering human-like physiological models. Goal(s): We aimed at describing age-related changes in brain hemodynamics and their potential interest as early markers of normal/pathological ageing. Approach: We analyzed blood flow in intracranial arteries and sinuses by using ECG-synchronized PCMRI. Results: The arterial (basilar trunk and carotids) inflow and venous (inferior and superior sinuses ) outflow sequence is earlier and shorter along the cardiac cycle in old versus young adult marmoset brains. Consequently, neurofluid oscillations appear different during the cardiac cycle as a function of age. Impact: Our study highlights the importance of nonhuman primate models in studying age-related cerebrovascular changes, offering insights into the link between vascular health, brain ageing, and cognitive decline, with implications for early neurodegenerative diseases.