Brain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan
Motivation: How loss of vascular health in aging leads to loss of brain function remains unexplained, since paradoxically brain energy consumption is close to normal. Goal(s): Our goal is to determine whether the loss of vascular health impacts the tissue accumulation of metabolic nutrients and waste products, which may interfere with brain function. Approach: We exploited Homeostatic Modeling to obtain brain maps of pCO2, pO2 and pH from two retrospective PET and MRI datasets. Results: Our results show that reduced vascular health in the elderly leads to regional loss of pCO2, pO2, and pH homeostasis of potential clinical significance. Impact: Determining whether impaired vascular health results into loss of homeostasis of metabolic waste products is critical to guide interventions that improve or preserve brain health in aging and beyond, including neurological conditions such as dementia, stroke, and traumatic brain injury.
Authors
- Mauro DiNuzzo (ORCID: https://orcid.org/0000-0003-0181-5597)
- Gerald A. Dienel (ORCID: https://orcid.org/0000-0001-8887-3057)
- Shalom Michaeli (ORCID: https://orcid.org/0000-0001-5426-8369)
- Pavel Filip (ORCID: https://orcid.org/0000-0001-5656-5164)
- Douglas L. Rothman (ORCID: https://orcid.org/0000-0001-9321-4195)
- Federico Giove (ORCID: https://orcid.org/0000-0002-6934-3146)
- Helene Benveniste (ORCID: https://orcid.org/0000-0002-2887-6667)
- Kevin L. Behar (ORCID: https://orcid.org/0000-0003-1467-0446)
- Silvia Mangia (ORCID: https://orcid.org/0000-0001-6341-4516)
- Xiufeng Li (ORCID: https://orcid.org/0000-0002-0764-4613)
- Michael Wolf (ORCID: https://orcid.org/0000-0002-6552-0125)
- S. Herculano
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3889
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00