Relationship Between Apparent Fiber Density in Corpus Callosum and Cognitive Function.

Motivation: Evaluation of fiber density in the corpus callosum (CC) is expected to show a higher sensitivity in relation to cognitive function than changes in volume. Goal(s): The goal is to clarify the association between the volume and AFD of the CC5 region and neuropsychological test scores. Approach: We examined the relationship between neuropsychological test scores, and calculated AFD and CC volume for 180 patients with suspected dementia. Results: CC volume showed no significant association with neuropsychological test scores. On the other hand, AFD showed associations with several neuropsychological tests. Impact: This study demonstrated that AFD correlated better with cognitive function than the previously reported CC volume. It was indicated the superior sensitivity of AFD in assessing cognitive function in dementia diagnosis.