Functional MRI of the nose
Motivation: Standard fMRI techniques are unable to image the nasal cavity due to strong susceptibility artefacts. Goal(s): Our goal is to exploit ultrashort or zero echo time imaging to study functional connectivity of the nose. Approach: Resting-state fMRI was performed on 5 humans at 7T and 1 mouse at 9.4T. Independent component analysis (ICA) was performed, and ICA signals were analyzed within the context of other physiological signals. Results: Highly reproducible nose networks were observed in humans. The signal of one network strongly correlated with the autonomic nervous system activity. A pronounced nose network was also observed in the mouse. Impact: Ultrashort and zero echo time fMRI enables unprecedented performance for detecting functional nose networks providing the means to study nose activity and system-wide connections between central and peripheral nervous systems not currently possible with standard fMRI for the first time.
Authors
- Jaakko Paasonen (ORCID: https://orcid.org/0000-0002-1529-596X)
- Petteri Stenroos (ORCID: https://orcid.org/0000-0002-4733-5014)
- Michael Garwood (ORCID: https://orcid.org/0000-0003-1578-9166)
- Shalom Michaeli (ORCID: https://orcid.org/0000-0001-5426-8369)
- Pavel Filip (ORCID: https://orcid.org/0000-0001-5656-5164)
- Douglas L. Rothman (ORCID: https://orcid.org/0000-0001-9321-4195)
- Edward J. Auerbach (ORCID: https://orcid.org/0000-0003-4553-1545)
- Olli Gröhn (ORCID: https://orcid.org/0000-0003-1372-1651)
- Ekaterina Paasonen (ORCID: https://orcid.org/0000-0003-2365-865X)
- Sara Ponticorvo (ORCID: https://orcid.org/0000-0002-7933-1608)
- Gregory J. Metzger (ORCID: https://orcid.org/0000-0002-3187-6529)
- Silvia Mangia (ORCID: https://orcid.org/0000-0001-6341-4516)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1296
- Primary Topic
- Advanced Chemical Sensor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00