Fast imaging of intravenous Gadolinium-based contrast agents entrance into ventricular CSF via choroid plexus in healthy subjects

Motivation: Intravenously administered gadolinium-based-contrast-agents (GBCAs) can enter the lateral-ventricle (LV) via choroid-plexus (CP). However, systematic investigation of GBCA accumulation in ventricular CSF via CP in healthy subjects is limited. Goal(s): To measure GBCA-induced signal changes in the LV and CSF around CP immediately and 4 hours after intravenous GBCA administration. Approach: Dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was performed in 25 healthy subjects. Results: At ~20s post-GBCA, GBCA-induced signal changes were detected in the CSF around CP but not in the rest of LV. After 4 hours, GBCA-induced signal changes also became significant in the entire LV. GBCA-amount in the LV showed an age correlation. Impact: These results provided direct imaging evidence that intravenous GBCA can pass the BCSFB in the CP and enter ventricular CSF in healthy subjects.

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Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/0036
Primary Topic
Lanthanide and Transition Metal Complexes
Type
article
Field-Weighted Citation Impact
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article

Fast imaging of intravenous Gadolinium-based contrast agents entrance into ventricular CSF via choroid plexus in healthy subjects

Linda Knutsson, Adrian Paez, Peter B. Barker, Arnold B. Bakker et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Lanthanide and Transition Metal Complexes
article

Fast imaging of intravenous Gadolinium-based contrast agents entrance into ventricular CSF via choroid plexus in healthy subjects

Linda Knutsson, Adrian Paez, Peter B. Barker, Arnold B. Bakker, Peter C.M. van Zijl, Jay J. Pillai, Bryan K. Ward, Jun Hua, Jacob M. Pogson, Yinghao Li, Di Cao, Yuanqi Sun
article en

Abstract

Motivation: Intravenously administered gadolinium-based-contrast-agents (GBCAs) can enter the lateral-ventricle (LV) via choroid-plexus (CP). However, systematic investigation of GBCA accumulation in ventricular CSF via CP in healthy subjects is limited. Goal(s): To measure GBCA-induced signal changes in the LV and CSF around CP immediately and 4 hours after intravenous GBCA administration. Approach: Dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was performed in 25 healthy subjects. Results: At ~20s post-GBCA, GBCA-induced signal changes were detected in the CSF around CP but not in the rest of LV. After 4 hours, GBCA-induced signal changes also became significant in the entire LV. GBCA-amount in the LV showed an age correlation. Impact: These results provided direct imaging evidence that intravenous GBCA can pass the BCSFB in the CP and enter ventricular CSF in healthy subjects.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 87%
Lanthanide and Transition Metal Complexes
DOISourceOpenAlex
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Fast imaging of intravenous Gadolinium-based contrast agents entrance into ventricular CSF via choroid plexus in healthy subjects — Linda Knutsson, Adrian Paez, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024) | TGRS Research Map | TGRS