PSMA PET/CT and mpMRI discrepancies in prostate cancer detection with whole-mount histopathology gold standard
Motivation: In prostate cancer (PCa), multiparametric MRI (mpMRI) and PSMA-PET aid pre-surgical assessment. This study evaluates parameters linked to the agreement/disagreement of PSMA-PET and mpMRI with histopathology. Goal(s): To evaluate the concordance between PSMA-PET, mpMRI, and histopathology in PCa lesion identification. Approach: Patients with PSMA-PET, mpMRI, and histopathology data were analyzed. Imaging lesions were contoured independently. Sensitivity and agreement were assessed. Logistic regression models examined factors affecting concordance. Results: Among 114 patients, PSMA-PET and mpMRI identified 170 and 138 lesions, respectively. Tumor aggressiveness and size impacted agreement. Higher SUVmax on PSMA-PET and higher ISUP grade and size on pathology were associated with concordance. Impact: This work improves prostate cancer diagnosis by identifying key factors influencing the agreement between PSMA-PET, mpMRI, and histopathology, offering valuable insights for more precise pre-surgical assessments.
Authors
- Hye Ok Kim (ORCID: https://orcid.org/0000-0002-9983-7438)
- Preeti Ahuja (ORCID: https://orcid.org/0000-0002-1768-0941)
- William W.Y. Hsu (ORCID: https://orcid.org/0000-0002-5168-070X)
- Adam B. Weiner (ORCID: https://orcid.org/0000-0002-1912-042X)
- Jérémie Calais (ORCID: https://orcid.org/0000-0002-8839-4379)
- Nashla Barroso
- Anthony Sisk (ORCID: https://orcid.org/0000-0001-7262-3985)
- M. S. Deol (ORCID: https://orcid.org/0000-0003-2429-9476)
- Ida Sonni (ORCID: https://orcid.org/0000-0002-8802-7704)
- Priti Soin (ORCID: https://orcid.org/0000-0002-6315-8281)
- Steven S. Raman (ORCID: https://orcid.org/0000-0003-0499-1676)
- David Ban (ORCID: https://orcid.org/0000-0002-3153-3104)
- Tristan Grogan (ORCID: https://orcid.org/0000-0001-9471-2938)
- Sahith Doddipalli
- Yang Zong (ORCID: https://orcid.org/0009-0008-9950-8184)
- Robert Reiter
- Johannes Czernin
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3336
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00