In vivo imaging of cerebral glucose metabolism of GLP-1R knockout mice with deuterium magnetic resonance spectroscopy

Motivation: The regulation of brain glucose metabolism by GLP1-1R has not been fully verified. Goal(s): To explore feasibility of dynamic DMRS in mice brain, and the physiological role of GLP-1R in mouse brain glucose metabolism. Approach: we apply DMRS and FDG-PET to quantify dynamic cerebral glucose change, and combine with rs-fMRI to investigate changes in whole-brain functional connectivity. Results: GLP-1R KO mice exhibit impaired brain glucose metabolism and central nervous system intolerance to high doses of exogenous glucose. And the functional brain connectivity in GLP-1R KO mice was significantly lower than that in WT group.Impact: The decline in functional connectivity may hinder the coordination of work and information transmission between brain regions, thus inhibit normal metabolic regulatory processes. These findings provide a theoretical basis for the treatment strategies of disorders related to brain glucose metabolism