The Correlation between Choroid Plexus and Protein Biomarkers in the Alzheimer’s Disease

Motivation: Dysfunction of the glymphatic system is one of the possible causes of Alzheimer’s disease (AD). We hypothesize that the choroid plexus (CP), the major site of CSF secretion, is associated with the hallmarks of AD, Aβ and tau protein deposition. Goal(s): to investigate the association between CP and hallmark proteins in the AD. Approach: Based on the proposed CP segmentation pipeline, univariate regression and stepwise regression models were employed to analyse correlations between CP and AD. Results: Our work shows that the ratio between CP and parenchyma is correlated with Aβ42 and p-tau (p<0.001) and the CP volume is correlated with t-tau (p<0.001). Impact: The proposed CP segmentation pipeline provided improved sensitivity to detect the correlations between CP/parenchyma ratio and Aβ42 and p-tau. This work may indicate the choroid plexus a possbile biomarker for AD.