Impact of Gender on Alzheimer’s disease: a Behavioral and Metabolic Analysis in AβPP-PS1 Mouse Model

Motivation: Sex specific status of neurometabolic activity in Alzheimer’s disease is poorly understood. Goal(s): To assess glutamatergic and GABAergic neurometabolism in different brain regions of male and female AβPP-PS1 mouse model of AD. Approach: Tracer approach involving infusion of [1,6-13C2]glucose in AβPP-PS1 mouse model of AD together with 1H-[13C]-NMR spectroscopy was used to estimate rate of neuronal Glucose oxidation (CMRGlc(Ox)) in AD mice. Results: The neuronal metabolic activity reduced in the cerebral cortex, hippocampus and cerebellum of female AβPP-PS1 mice. However, only hippocampal neurometabolic activity was reduced in the male mice. This suggests a differential progression of AD in male and female AβPP-PS1 mice. Impact: The findings of the study suggest differential progression of AD in male and female AβPP-PS1 mice. These factors require attention for future interventions for AD treatment.