Integration of Whole Brain Spectroscopic Imaging in Planning Workflow for Personalized Delivery of TTFields in Glioblastomas
Motivation: Optimal treatment for GBM requires precise targeting of all viable tumor cells, many of which are not visible on conventional neuroimaging. Goal(s): We aimed to utilize WBSI to identify infiltrating tumor cells in GBM patients for selecting a precise target volume for personalized mapping of transducer arrays for enhanced delivery of TTFields. Approach: A mean value of choline/NAA was computed from normal mask, and all voxels that exceeded two-fold threshold value were included in a 3D-composite mask from the tumor region. Results: WBSI provided higher yield of voxels with good spectral quality, resulting in improved brain tumor coverage compared to anatomical MRI sequences. Impact: Alternative array configuration created from WBSI will allow precise delineation of tumor margins for enhanced delivery of TTFields dose to all proliferating regions of a GBM, decreasing the rate of local recurrence and ultimately improving overall survival.
Authors
- Stephen Bagley (ORCID: https://orcid.org/0000-0002-7117-0539)
- Stephanie E. Weiss (ORCID: https://orcid.org/0000-0003-2365-4296)
- Nduka Amankulor (ORCID: https://orcid.org/0000-0001-6217-1954)
- Laiz Laura de Godoy (ORCID: https://orcid.org/0000-0001-5956-5741)
- Raju V. Shah (ORCID: https://orcid.org/0000-0001-9532-4080)
- Brian B. Berger (ORCID: https://orcid.org/0000-0002-8639-1756)
- Demetrius Ribeiro de Paula (ORCID: https://orcid.org/0000-0003-0590-8694)
- Lisa Desiderio
- Sanjeev Chawla (ORCID: https://orcid.org/0000-0001-6978-7284)
- Ashok K. Giri (ORCID: https://orcid.org/0000-0002-2646-4087)
- MacLean P. Nasrallah (ORCID: https://orcid.org/0000-0003-4861-0898)
- Scott H. Herbert
- Kheng Choon Lim (ORCID: https://orcid.org/0000-0001-7747-3453)
- Dawit Gebremichael Aregawi (ORCID: https://orcid.org/0009-0009-5506-3301)
- Rachelle Lanciano (ORCID: https://orcid.org/0000-0001-6051-1927)
- Suyash Mohan (ORCID: https://orcid.org/0000-0002-4025-115X)
- Demetrius Lee
- Ajitha Rajan (ORCID: https://orcid.org/0000-0003-3765-3075)
- Varsha Jain (ORCID: https://orcid.org/0000-0002-0764-5894)
- Atom Sarkar (ORCID: https://orcid.org/0000-0002-8164-7150)
- Gaurav Shukla (ORCID: https://orcid.org/0000-0001-7094-9797)
- Sulaiman Sheriff (ORCID: https://orcid.org/0009-0007-2491-2273)
- Kristina Vineis
- A. Padmanabhan
- Tara Morrison
- Sunjay Shah
- Srilatha Hosur
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0399
- Primary Topic
- Machine Learning in Materials Science
- Type
- article
- Field-Weighted Citation Impact
- 0.00