Apparent diffusion coefficient as a non-contrast marker of residual disease after breast neoadjuvant treatment
Motivation: Accurate imaging markers to establish pathologic complete response (pCR) during neoadjuvant chemotherapy (NACT) could enable therapy de-escalation to avoid excessive systemic treatmentsGoal(s): To determine if quantitative diffusion-weighted MRI (DWI) can accurately detect pCR following NACT. Approach: In the ACRIN 6698/I-SPY 2 multicenter trial dataset, tumor region apparent diffusion coefficient (ADC) from DWI was measured on post-NACT/presurgical MRIs. The accuracy of ADC for predicting pCR, alone and in combination with functional tumor volume (FTV) from contrast-enhanced MRI, was assessed. Results: In multivariate models ADC accurately predicts pCR, and is influenced by field strength, spatial resolution, and lesion morphology. Impact: Apparent diffusion coefficient measured by DWI shows promise for determining absence of residual disease following chemotherapy and may provide a non-contrast option for tailoring therapies and enabling patients to avoid unnecessary prolongation of treatment.
Authors
- Rebecca Rakow‐Penner (ORCID: https://orcid.org/0000-0002-2566-1978)
- Savannah C. Partridge (ORCID: https://orcid.org/0000-0001-6370-9111)
- Bonnie N. Joe (ORCID: https://orcid.org/0000-0001-9333-1463)
- Stéphane Loubrie (ORCID: https://orcid.org/0009-0009-0526-2281)
- Jessica Gibbs (ORCID: https://orcid.org/0000-0003-1785-0899)
- Lisa J. Wilmes
- Nola M. Hylton (ORCID: https://orcid.org/0000-0002-6747-1662)
- Anum S. Kazerouni (ORCID: https://orcid.org/0000-0002-4200-534X)
- Beatriu Reig (ORCID: https://orcid.org/0000-0002-6577-8601)
- Elizabeth S. McDonald (ORCID: https://orcid.org/0000-0002-7209-4216)
- Nu Le
- Debasis Biswas (ORCID: https://orcid.org/0000-0002-7557-3693)
- Patrick J. Bolan (ORCID: https://orcid.org/0000-0002-4194-3975)
- An Church (ORCID: https://orcid.org/0000-0002-9544-8638)
- Dariya Malyarenko (ORCID: https://orcid.org/0000-0003-0403-1501)
- Elissa R. Price (ORCID: https://orcid.org/0000-0001-9572-7795)
- Hon J. Yu (ORCID: https://orcid.org/0000-0002-2815-6475)
- Wen Li (ORCID: https://orcid.org/0000-0002-9550-3828)
- Thomas Chenervert
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0203
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00