Choroid Plexus Structural and vascular Changes Associated with Aging in the HCP Dataset

Motivation: Analyzing ChP changes in normal aging is essential for grasping its role in neurological disorders. Goal(s): To evaluate ChP changes with age using diffusion and perfusion MRI in a lifespan HCP-aging dataset. Approach: MR images of 641 healthy participants aged from 36 to 90 years old were analyzed to extract diffusion and perfusion measurements of ChP to investigate their age-related changes. Results: With age, the ChP undergoes significant changes, including increased volume, reduced blood flow, elevated MD values, and a more rapid decline in blood flow compared to gray and white matter. Impact: This study offers a comprehensive evaluation of age-related changes in the ChP, enhancing our comprehension of its potential involvement in age-related cognitive decline. Furthermore, age-related ChP alterations exhibit distinct patterns compared to changes in gray and white matter.