Prolonged Central Thalamic Intermittent Theta-Burst Stimulation Rescued Memory Deficits in Alzheimer's Disease Mouse Model

Motivation: Addressing the global AD crisis by investigating CT-iTBS as a non-pharmacological treatment to enhance memory and cognition. Goal(s): To explore the therapeutic efficacy and determine the optimal treatment protocol of CT-iTBS in AD while unveiling its potential underlying mechanism for enhancing memory and cognitive functions. Approach: Utilized brain magnetic resonance imaging analysis, behavioral tests, and immunofluorescence staining for assessing the therapeutic effect of different durations of CT-iTBS treatment. Results: Prolonged CT-iTBS significantly enhanced cognitive and memory behaviors, altered brain functional connectivity, promoted a neuroprotective effect, and reduced amyloid accumulation in AD mouse model. These findings present a promising therapeutic avenue for AD patients. Impact: Our findings revealed a highly promising avenue for enhancing the quality of life for individuals with AD and provided insights into the potential underlying neuroprotective mechanisms of CT-iTBS in alleviating memory deficits.