Improved diagnostic value for prostate cancer with bpMRI PI-RADS v2.1 integrating quantitative synthetic magnetic resonance imaging

Motivation: It’s essential to explore new imaging methods to improve the diagnostic performance of bp-MRI (T2W+DWI) PI-RADS v2.1 in the absence of DCE. Goal(s): To evaluate the potential of quantitative relaxometry from synthetic MRI in combination with bp-MRI PI-RADS v2.1 score for differentiating clinically significant prostate cancer. Approach: T2WI, T2WI fs, DWI and synthetic MRI with magnetic resonance image compilation (MAGiC) imaging in 3T MRResults: Integrating T1, T2, PD and ADC with PI-RADS score improves the diagnostic performance for lesions in peripheral zone significantly with increased both sensitivity and specificity, but not significantly for the lesions in transitional zone. Impact: The introduction of relaxometry from synthetic MRI can help improve the diagnostic efficiency in the peripheral zone when integrated with PI-RADS in the absence of DCE, which avoid the increase of peripheral zone lesions with PI-RADS score of 3.