Integrated B0 and B1 mapping and image correction for hyperpolarized Carbon-13 metabolic imaging in the human brain

Motivation: B0 and B1 inhomogeneities affect signal quantification and kinetic modelling but are challenging to map and correct for in hyperpolarized MRI due to the signal being exogenous and non-renewable. Goal(s): Develop a fully-integrated B0 and B1 mapping method that does not require specialized pulse sequence programming, additional hardware, nor any additional carbon-13 dose. Approach: Varying echo times and flip angles in the imaging sequence. Results: The in-vivo field maps agreed well with independently acquired maps and could correct for B0 off-resonance blurring and B1 inhomogeneity. Impact: A fully-integrated B0 and B1 mapping and correction method for hyperpolarized carbon-13 MRI is presented and validated in vivo. This method is readily implemented and can improve image quality, helping 13C metabolic imaging become more robust for clinical studies.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/3034
Primary Topic
Advanced NMR Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Integrated B0 and B1 mapping and image correction for hyperpolarized Carbon-13 metabolic imaging in the human brain

Kylie Yeung, Sarah Birkhoelzer, Rolf F. Schulte, Damian J. Tyler et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced NMR Techniques and Applications
article

Integrated B0 and B1 mapping and image correction for hyperpolarized Carbon-13 metabolic imaging in the human brain

Kylie Yeung, Sarah Birkhoelzer, Rolf F. Schulte, Damian J. Tyler, Oliver J. Rider, Jordan McGing, Jenny Rayner, Fergus Gleeson, James T. Grist, Ayaka Shinozaki, Andrew Lewis, Aaron Axford
article en

Abstract

Motivation: B0 and B1 inhomogeneities affect signal quantification and kinetic modelling but are challenging to map and correct for in hyperpolarized MRI due to the signal being exogenous and non-renewable. Goal(s): Develop a fully-integrated B0 and B1 mapping method that does not require specialized pulse sequence programming, additional hardware, nor any additional carbon-13 dose. Approach: Varying echo times and flip angles in the imaging sequence. Results: The in-vivo field maps agreed well with independently acquired maps and could correct for B0 off-resonance blurring and B1 inhomogeneity. Impact: A fully-integrated B0 and B1 mapping and correction method for hyperpolarized carbon-13 MRI is presented and validated in vivo. This method is readily implemented and can improve image quality, helping 13C metabolic imaging become more robust for clinical studies.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 84%
Advanced NMR Techniques and Applications
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.