Hyperpolarize imaging of fructolysis in fed vs fasted mice liver

Motivation: Fructose intake has increased 80-times over the past century, although the effect of this increase in the body remains unclear. Goal(s): To assess the metabolic flux of fructose at different metabolic states (fed vs fasted) for future human studies. Approach: Fed or fasted mice were injected with hyperpolarized fructose to observe metabolic flux. Results: Fed mice showed the formation of glucose (gluconeogenesis) by F1P, while fasted mice metabolized the fructose to obtain energy. Impact: The results pressented have significant implications for the understanding of fructoylsis and provides a translational metabolic imaging strategy for future human studies.