Signal intensity and volume of carotid intraplaque hemorrhage on MRI and ipsilateral cerebrovascular events: the Plaque At RISK (PARISK) study
Motivation: The presence of intraplaque hemorrhage (IPH) is a strong independent stroke predictor. Higher IPH signal intensity ratios (SIR) and volumes were found in symptomatic versus asymptomatic carotid arteries. Goal(s): To determine if IPH SIR and volume are associated with the risk for ipsilateral ischemic neurovascular events in symptomatic patients with <70% carotid stenosis. Approach: Cox proportional hazards and logistic regression were used to explore the association of IPH SIR and volume to ipsilateral ischemic neurovascular events in 87 IPH-positive patients. Results: IPH SIR and IPH volume were not associated with risk for ipsilateral ischemic events during 5.1(IQR:3.1-5.6) years. Impact: No association was found between IPH SIR or volume and the risk for ipsilateral ischemic neurovascular events or new infarcts on brain MRI. Therefore, identifying the presence of IPH is sufficient for risk stratification.
Authors
- M. Eline Kooi (ORCID: https://orcid.org/0000-0001-7562-5724)
- Werner H. Mess (ORCID: https://orcid.org/0000-0002-9736-9941)
- Paul J. Nederkoorn (ORCID: https://orcid.org/0000-0001-7386-4545)
- Alida A. Postma (ORCID: https://orcid.org/0000-0002-1116-054X)
- Rob J. van der Geest (ORCID: https://orcid.org/0000-0002-9084-5597)
- Dianne H.K. van Dam-Nolen (ORCID: https://orcid.org/0000-0002-4527-3876)
- Kelly Nies (ORCID: https://orcid.org/0000-0002-9457-3306)
- Jeroen Hendrikse (ORCID: https://orcid.org/0000-0001-6384-6140)
- Mueez Aizaz (ORCID: https://orcid.org/0000-0002-9078-8924)
- Daniël Bos (ORCID: https://orcid.org/0000-0001-8979-2603)
- Timothy Goring
- Robert van Oostenbrugge
- Tobien H.C.M.L. Schreuder
- Narender van Orshoven
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3390
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00