Multiparametric MRI to study changes across the Surgical Journey in Bariatric Patients with Type 2 diabetes or Prediabetes.

Motivation: Bariatric surgery is evaluated by weight loss and diabetes remission, but the mechanism of the latter is unclear. Goal(s): Use MRI to quantify changes in liver, pancreas and subcutaneous adipose tissue (SAT). Approach: Multiparametric MRI of fat fraction (FF), T2*, volume, T1 and T2 at four timepoints before and after bariatric surgery. Results: Significant reduction in liver FF from baseline to 6-weeks, and between post-VLCD and 6-weeks, and liver volume from baseline to subsequent time points. Compared to baseline a significant increase in liver T2* at 6-weeks, reduction in liver T1 at 6-weeks and 6-months, and decrease in SAT at 6-monthsImpact: Multiparametric MRI assessment of changes in liver and pancreas fat, volume and T1, T2* and T2 relaxometry, as well as subcutaneous volume associated with bariatric surgery may serve as markers for longitudinal and cross-sectional assessment of patients.