Histology-informed biophysical diffusion MRI model selection for enhanced liver cancer immunotherapy assessment
Motivation: Multi-compartment liver diffusion MRI (dMRI) provides innovative markers of intra-cellular fraction (F) and cell size (CS). However, practical implementations for histologically-meaningful F and CS computation in the clinic are still sought. Goal(s): To deliver a compact approach for F and CS estimation, informing model design with histology. Approach: We compared 5 implementations of a standard two-compartment model for their ability to provide F and CS estimates that agree with reference biopsies in liver tumours. Results: The best approach consisted of fitting a single-compartment model of intra-cellular diffusion to high b-value images. This provides promising metrics that stratify the risk of progression in immunotherapy. Impact: We deliver a clinically-feasible liver diffusion MRI approach for intra-cellular fraction, cell size and density estimation. It consists of fitting a single-compartment model of restricted diffusion to high b-value images, and provides metrics that may inform on cancer immunotherapy response.
Authors
- María Vieito (ORCID: https://orcid.org/0000-0001-7531-343X)
- Kinga Bernatowicz (ORCID: https://orcid.org/0000-0001-9166-1709)
- Xavier Merino (ORCID: https://orcid.org/0000-0002-1985-9363)
- Núria Rosón (ORCID: https://orcid.org/0000-0001-6751-7491)
- Raquel Pérez-López (ORCID: https://orcid.org/0000-0002-9176-0130)
- Francesco Grussu (ORCID: https://orcid.org/0000-0002-0945-3909)
- Carol A. Tozzi
- Manuel Escobar (ORCID: https://orcid.org/0000-0002-3794-2224)
- Garazi Serna (ORCID: https://orcid.org/0000-0003-2666-0982)
- S. Simonetti (ORCID: https://orcid.org/0000-0003-2406-030X)
- Elena Garralda (ORCID: https://orcid.org/0000-0002-4412-7842)
- Marco Palombo (ORCID: https://orcid.org/0000-0003-4892-7967)
- Richard Mast (ORCID: https://orcid.org/0000-0001-6005-800X)
- Paolo Nucíforo (ORCID: https://orcid.org/0000-0003-1380-0990)
- Juan Francisco Corral (ORCID: https://orcid.org/0000-0002-8699-4186)
- Pablo García‐Polo García
- Marta Vidorreta (ORCID: https://orcid.org/0000-0002-4272-3691)
- Valezka Garay
- Athanasios Grigoriou (ORCID: https://orcid.org/0000-0003-1826-8040)
- R.D.A. Toledo
- Anna Voronova (ORCID: https://orcid.org/0009-0006-9600-0436)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0649
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00