Early Detection Of Heart Failure By Visualizing Redox Metabolism Using In Vivo Dynamic Nuclear Polarization MRI

Motivation: The diagnosis of heart failure is based on clinical symptoms because noninvasive methods for early diagnosis are still insufficient. Goal(s): Considering reactive oxygen species contribute to heart failure, we hypothesized much earlier signs of heart failure could be captured by focusing on redox metabolism. Approach: We used a doxorubicin-induced mouse model of heart failure and analyzed at an early stage. To visualize redox metabolism, we used in vivo dynamic nuclear polarization MRI. We also evaluated the cardiomyocytes microscopically. Results: The intracardiac redox metabolism was enhanced in 30 min after doxorubicin administration compared to the control group although no significant cardiomyocyte changes were observed. Impact: In the early stages of heart failure, redox metabolism is altered even before the morphological changes are observed microscopically. These data provide a technique for detecting heart failure earlier and less invasively than conventional testing methods.