Assessment of rhabdomyolysis-induced acute kidney injury with chemical exchange saturation transfer MRI
Motivation: There is a gap in exploring the progression of acute kidney injury (AKI) caused by rhabdomyolysis (RM). Goal(s): Investigate the feasibility of CEST MRI for assessing the progression of RM-induced AKI in a mouse model. Approach: The RM-AKI model was established by intramuscular injection of glycerol solution and examined longitudinally by CEST (days 1, 3, 7, 15, 30). CEST quantification parameters and their diagnostic performance were compared. Results: MTR presented a significant difference, and showed the best diagnostic performance for AKI and moderate negative correlations with pathological changes. Impact: MTR has potential clinical utility for assessing renal diseases.
Authors
- Yanqiu Feng (ORCID: https://orcid.org/0000-0002-2807-5974)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0003-1294-7325)
- Zelong Chen
- Zhigang Wu (ORCID: https://orcid.org/0000-0002-6931-6498)
- Thoralf Niendorf (ORCID: https://orcid.org/0000-0001-7584-6527)
- Erdmann Seeliger (ORCID: https://orcid.org/0000-0002-5685-8044)
- Kan Deng (ORCID: https://orcid.org/0000-0001-9571-3705)
- Quan Tao (ORCID: https://orcid.org/0000-0002-1139-5058)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0705
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00