ABRICOTINE MRI: Enhancing Sparsity Across the Three Dimensions of the Fourier Domain in Cartesian Sampling

Motivation: With the increasing demand for high-resolution and short MRI exams, especially at high and ultra-high field, there is a need for fast acquisition techniques. Goal(s): To improve highly accelerated compressed-sensing by introducing a novel sampling named Alternating Basis Readout Imaging with COmpressed$$$\,$$$sensing with Three-dImensioNal Encoding (ABRICOTINE). Approach: ABRICOTINE incorporates sparse phase-encoding in three orthogonal directions, achieving true three-dimensional undersampling of the Fourier domain. This differs from conventional compressed$$$\,$$$sensing, which only undersamples within two phase-encoding dimensions. Results: We demonstrate significant enhancements in brain image quality through both simulations and true ABRICOTINE-accelerated acquisitions. It surpasses conventional compressed$$$\,$$$sensing methods and enables 0.5mm isotropic imaging in 4min. Impact: ABRICOTINE allows for a substantial improvement in compressed-sensing acceleration compared to traditional sparse sampling techniques, especially when high acceleration factors are required. It thus shows great potential for further accelerating high resolution MRI acquisitions.