Liver T1, T2 and ADC Magnetic Resonance Fingerprinting in a single breath-hold

Motivation: Single breath-hold simultaneous T1, T2 and ADC abdominal Magnetic Resonance Fingerprinting (MRF) in liver would allow for fast and comprehensive liver tissue characterization. Goal(s): To develop a fast MRF sequence for T1, T2 and ADC quantification on liver tissue in a single breath-hold at 3TApproach: Radial spoiled-GRE ~16-second acquisition with magnetization preparation modules for T1, T2 and ADC encoding was proposed, with an optimized diffusion-preparation module. Sequence was evaluated in phantoms and in 11 healthy subjects. Results: T1, T2 and ADC quantification shows good correlation with reference maps in phantoms and good agreement in vivo against clinical scans. Impact: Simultaneous quantification of T1, T2 and ADC in liver tissue in a single-scan is now possible with this proposed MRF sequence, allowing for a more comprehensive evaluation of hepatic disease through co-registered multiparametric imaging.